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Soujanya, B.
- Influence of Casting Solvent and Polymer on Permeability of Propranolol Hydrochloride through Eudragit RL100 and Eudragit RLPO Films
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Authors
Affiliations
1 Bapatla College of Pharmacy, Bapatla, IN
2 Department of Analysis, Bapatla College of Pharmacy, Bapatla, IN
3 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, IN
4 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN
1 Bapatla College of Pharmacy, Bapatla, IN
2 Department of Analysis, Bapatla College of Pharmacy, Bapatla, IN
3 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, IN
4 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 1 (2015), Pagination: 69-73Abstract
In the present work, eudragitL100and Eudragit RLPO films were prepared and evaluated as rate controlling membrane for transdermal drug delivery systems. Dibutyl phthalate or propylene glycol at a concentration of 15w/w of the polymer was used as a plasticizer in the preparation of eudragitL100and Eudragit RLPO films. Casting on mercury surface technique was employed for preparation of eudragitL100and Eudragit RLPO films. The dry films were evaluated for physical appearance, water vapour transmission, drug diffusion and permeability coefficient. Both water vapour transmissions, drug diffusion rate followed zero-order kinetics. The mechanism of drug release was governed by peppas model. The diffusion exponent of release profiles (slope) has a value of 1.056-1.071 (n>1), which indicates super case ц transport diffusion. The results obtained in the present study thus indicate that the polymer and solvents used in the preparation of films have shown significant influence on the water vapour transmission, drug diffusion and permeability of the films.Keywords
Polymer, Solvents, Water Vapour Transmission, Drug Diffusion and Permeability Coefficient.- Studies on Influence of Process and Formulation Variables on Performance of Omeprazole Pellets
Abstract Views :184 |
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Authors
Affiliations
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN
2 Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN
2 Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 1 (2015), Pagination: 21-29Abstract
The objective of the present study is to formulate and evaluate delayed release pellets of Omeprazole and to protect the drug from gastric fluids. The pellets were processed by employing FBC. The drug and excipient interaction studies were conducted with IR spectral studies and drug and the selected excipient were found to be compatible. Various process variables such as inlet air temperature, pump RPM, atomization air pressure, %damper opening, spray rate and formulation variables such as the concentration of alkalizing agent CaCo3, surfactant SLS and binder PVP in drug loading, the concentration of sub coating material HPMCE5 in barrier coating and the enteric coating material eudragitL30D55,the plasticizer PEG6000 were studied. The parameters such as exhaust air temperature, product temperature, physical appearance, size and size distribution, drug content, friability, acid resistance, moisture content and drug release were monitored during the study. Processing was found to be better when the inlet air temperature (50-600c), spray rate (1-6rpm), %damper opening (6.5-7) and atomized air pressure (1.8 kgcm2) were maintained. The optimized concentrations of CaCo3, SLS and PVP were found to be 0.235%, 0.033%, 0.019% respectively for drug loading.0.947%w/w HPMCE5 was found to be suitable for barrier coating and0.0874%w/w eudragitL30D55, 0.0322%PEG6000, 0.0051% NaOH was found to be optimum for enteric coating. The finished dosage form was subjected to short term stability studies as for ICH guidelines and optimized formulation was found to be quite stable.Keywords
Omeprazole, Enteric Coating Polymer EudragitL30 D55, Sub Coating Polymer HPMCE5 Acid Resistance.- Studies on Influence of Coprocessed Excipients on Flow and Dissolution Kinetics of Diclofenac Sodium
Abstract Views :177 |
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Authors
Affiliations
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN
2 Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN
2 Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 1 (2015), Pagination: 51-58Abstract
Co-processed excipients with microcrystalline cellulose and guar gum, xanthan gum, almond gum, kondagogu in different ratios were fabricated by different methods and its influence on blend fluidity, friability of the tablet and dissolution characteristics of diclofenac sodium from direct compressible tablets was studied. The flow properties of the blends were determined by Carr's index and Hausner's ratio. Optimized co-processed formulation containing microcrystalline cellulose and guar gum in the ratio 1:3 was found to be more acceptable to formulate diclofenac sodium tablets. The co-processed excipients were prepared by using granulation technique. The preformulation parameters like flow property and the performance parameters were dependent on the proportion of components present in the co-processing excipient. The co-processed excipient prepared with granulation technique imparted the desired qualities to the tablet. The drug dissolution rate followed zero order kinetics. The mechanism of drug release was governed by peppas model. The dissolution exponent of release profiles(slope) has a value of 0.59-1.05(n>1), which indicates super case ц transport diffusion. The drug and excipient interaction studies were conducted with IR spectral studies and drug and the selected excipient were found to be compatible. The finished dosage form was subjected to short term stability studies as for ICH guidelines and optimized formulation was found to be quite stable. The results obtained in the present study thus indicate that the gums and its concentrations used in the preparation of tablets have shown significant influence on drug release rate.Keywords
Diclofenac Sodium, Co-Processed Excipients, Guar Gum, Xanthan Gum, Almond Gum, Kondagogu.- Co-Processing of Excipients:A Review on Excipient Development for Improved Tabletting Performance
Abstract Views :227 |
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Authors
Affiliations
1 Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN
2 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN
1 Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN
2 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, Guntur, Andhra Pradesh, IN